Preparation, Gram-Negative Antibacterial Activity, and Hydrolytic Stability of Novel Siderophore-Conjugated Monocarbam Diols
作者
FLANAGAN MARK E; BRICKNER STEVEN J; LALL MANJINDER; CASAVANT JEFFREY; DESCHENES LAURA; FINEGAN STEVEN M; GEORGE DAVID M; GRANSKOG KARL; HARDINK JOEL R; HUBAND MICHAEL D; THUY HOANG; LAMB LUCINDA; MARRA ANDREA; MITTONFRY MARK; MUELLER JOHN P; MULLINS LISA M; NOE MARK C; ODONNELL JOHN P; PATTAVINA DAVID; PENZIEN JOSEPH B; SCHUFF BRANDON P; SUN JIANMIN; WHIPPLE DAVID A; YOUNG JENNIFER; GOOTZ THOMAS D
[摘要]：A novel series of monocarbam compounds exhibiting promising antibacterial activity against multidrug resistant Gram-negative microorganisms is reported, along with the synthesis of one such molecule MC-1 (1). Also reported are structure-activity relationships associated with the in vitro and in vivo efficacy of 1 and related analogues in addition to the hydrolytic stability of such compounds and possible implications thereof.
