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[摘要]：Areas covered: This review summarizes the patent literature about the development of alpha alpha(2C)-AR modulators from 2000 to early 2010 and their therapeutic effects evoked by the interaction with this receptor subtype. Expert opinion: Over 90 patents have been deposited in the last 10 years regarding different methods of alpha alpha(2C)-AR modulation (use of agonists or antagonists, nucleic acids and polypeptides) for diagnosis, prognosis and treatment of disorders involving this receptor. Nevertheless, despite the numerous published patents, ligands highly selective for the alpha alpha(2C)-AR subtype, which continues to be enigmatic, are lacking. |
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