Synthesis and properties of triazole-linked RNA

[摘要]：RNA oligonucleotides having triazole linkages between uridine and adenosine nucleosides have been prepared and studied using spectroscopic techniques. UV melting and CD showed that triazole strongly destabilized RNA duplex (7-14 degrees C per modification). NMR data suggested that, despite relative flexibility around the modified linkage, all base pairs were formed. (C) 2011 Elsevier Ltd. All rights reserved.

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