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Rapid One-Pot, Four-Step Synthesis of Highly Fluorescent 1,3,4,5-Tetrasubstituted Pyrazoles

  作者 WILLY BENJAMIN; MUELLER THOMAS J J  
  选自 期刊  Organic Letters;  卷期  2011年13-8;  页码  2082-2085  
  关联知识点  
 

[摘要]1,3,4,5-Tetrasubstituted pyrazoles can be rapidly and efficiently synthesized in a one-pot, four-step sequence consisting of Sonogashira coupling, addition-cyclocondensation, bromination, and Suzuki coupling. The second and the last step are microwave-assisted, and according to sequential catalysis, no addition of further Pd catalyst is needed for the terminal step. The title compounds show intense blue fluorescence and high quantum yields.

 
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