[摘要]：Craniofacial reconstruction would benefit from a degradable adhesive capable of holding bone fragments in three-dimensional alignment and gradually being replaced by new bone without loss of alignment or volume changes Modeled after a natural adhesive secreted by the sandcastle worm we studied the biocompatibility of adhesive complex coacervates in vitro and in vivo with two different rat calvarial models We found that the adhesive was non-cytotoxic and supported the attachment spreading and migration of a commonly used osteoblastic cell line over the course of several days In animal studies we found that the adhesive was capable of maintaining three-dimensional bone alignment in freely moving rats over a 12 week indwelling period Histological evidence indicated that the adhesive was gradually resorbed and replaced by new bone that became lamellar across the defect without loss of alignment changes in volume or changes in the adjacent uninjured bone The presence of inflammatory cells was consistent with what has been reported with other craniofacial fixation methods including metal plates screws tacks calcium phosphate cements and cyanoacrylate adhesives Collectively the results suggest that the new broadhesive formulation is degradable osteoconductive and appears suitable for use in the reconstruction of craniofacial fractures (C) 2010 Elsevier Ltd All rights reserved
