SYNTHETIC STUDIES OF LEPRANTHIN, A LICHEN-PRODUCED DIMERIC MACROLIDE. STEREOSELECTIVE SYNTHESIS OF A SECO-ACID BASED ON STEREOSPECIFIC EPDXIDE-OPENING REACTIONS

[摘要]：The stereoselective synthesis of a seco-acid derivative of lepranthin (1), a lichen-produced unique 16-membered dimeric macrolide, is described wherein all asymmetric carbon centers were constructed in a highly stereoselective manner, respectively, by using different epoxide-opening reactions of the alpha,beta-unsaturated gamma,delta-epoxy ester system and an epoxy alcohol derivative as the key steps. [GRAPHICS] .

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