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[摘要]：One new and six known pentacyclic triterpenoids, 1 and 4-9, resp., along with two new and three known iridoid glycosides, 2 and 3, and 10-12, resp., were isolated from the roots of Gentiana dahurica ('Qin-Jiao'). The new structures were elucidated by means of spectroscopic and chemical methods as 1 beta,2 alpha,3 alpha,24-tetrahydroxyursa-12,20(30)-dien-28-oic acid (1), 6'-O-acetylgentiopicroside (2), and 3'-acetylgentiopicroside (3). Isolated compounds were tested for their cytotoxicity against the MCF-7 human breast cancer cell line using the MTT assay. Among them, triterpenoids 2 alpha,3 beta,24-trihydroxyurs-12-en-28-oic acid (6) and 3 beta,24-dihydroxyurs-12-en-28-oic acid (9) were found to have moderate cytotoxic effects with IC50 values of 20.9 and 21.7 mu g/ml, respectively. Additionally, the chemotaxonomic significance of the identified secondary metabolites is briefly discussed. |
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