Preparation of the beta(2)-Homoselenocysteine Derivatives Fmoc-(S)-beta(2)hSec(PMB)-OH and Boc-(S)-beta(2)hSec(PMB)-OH for Solution and Solid-Phase Peptide Synthesis

[摘要]：Fmoc-beta(2)hSer(Bu-t)-OH was converted to Fmoc-beta(2)hSec(PMB)-OH in five steps. To avoid elimination of HSeR, the selenyl group was introduced in the second last step (Fmoc-beta(2)hSer(Ts)-OAll -> Fmoc-beta(2)hSec(PMB)-OAll). In a similar way, the N-Boc-protected compound was prepared. With the beta(2)hSe-derivatives, 21 beta(2)-amino-acid building blocks with proteinogenic side chains are now available for peptide synthesis.

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