【文章名】Diastereoselective Synthesis of trans-2,3-Dihydrothiophenes via Multicomponent Reactions of Pivaloylacetonitrile, Aldehyde, Amine, and Thiazolidinedione
Diastereoselective Synthesis of trans-2,3-Dihydrothiophenes via Multicomponent Reactions of Pivaloylacetonitrile, Aldehyde, Amine, and Thiazolidinedione
[摘要]:Polyfunctionalized trans-2,3-dihydrothiophenes are efficiently synthesized from the four-component reactions of thiazolidine-2,4-dione, aromatic aldehydes, secondary amines, and pivaloylacetonitrile. The reaction mechanism involves Knoevenagel condensation, Michael addition, and characteristic ring-opening of thiazolidine-2,4-dione followed by an intramolecular ring-closure process