Preparation of Isoindolones by a Lithium-Iodide Exchange-Induced Intramolecular Wurtz-Fittig Reaction of o-Iodobenzoyl Chloride/Imine Adducts

[摘要]：Addition of o-iodobenzoyl chlorides to imines affords N-acyliminium ions, perhaps in equilibrium with alpha-chlorobenzamides, as adducts. Reaction of the adducts with 1.1 equivalents of phenyllithium at -78 degrees C followed by warming to ambient temperature induces an intramolecular Wurtz-Fittig coupling to afford 2,3-dihydroisoindolones in excellent yields.

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