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A Facile One-Pot Synthesis of 3-Imidazolyl 1,2,4-Triazoles and 1,2,4-Oxadiazolones

  作者 DIAS ALICE M; CABRAL ISABEL M; VILACHA A SOFIA; CUNHA DANIELA P; SENHORAES NADIA; NOBRE SANDRA M; SOUSA CRISTINA E; PROENCA M FERNANDA  
  选自 期刊  SYNLETT;  卷期  2010年-18;  页码  2792-2796  
  关联知识点  
 

[摘要]5-(5-Aminoimidazol-4-yl)-1,2,4-triazol-3-ones were obtained under mild experimental conditions from 5-amino-4-(N-ethoxycarbonyl) cyanoformimidoyl imidazoles and hydrazine in a rapid one-pot reaction. When hydroxylamine hydrochloride was used, in the presence of base, the corresponding 1,2,4-oxadiazol-5ones were isolated. An equally fast reaction occurred when 5-amino-4-(N-acetyl/benzoyl) cyanoformimidoyl imidazoles were combined with hydrazine to give 5-(5-aminoimidazol-4-yl)-1,2,4-triazoles.

 
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