Chiral Sodium Phosphate Catalyzed Enantioselective 1,4-Addition of TMSCN to Aromatic Enones

[摘要]：A facile enantioselective 1,4-addition of TMSCN to aromatic enones has been developed using chiral sodium phosphate. Thus, in the presence of 20 mol% of sodium salt generated in situ from (R)-3,3'-di(1-adamantyl)-1,1'-binaphthyl-2,2'-diylphosphoric acid and NaOH, beta-cyano ketones were obtained in high yield (86-96%) and up to 72% ee within three hours at 80 degrees C in toluene.

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