AN ENANTIO- AND DIASTEREOCONTROLLED SYNTHESIS OF (-)-SALINOSPORAMIDE A

[摘要]：The enantio- and diastereocontrolled total synthesis of (-)-salinosporamide A, a potent 20S proteasome inhibitor, was accomplished through organocatalytic aldolization, diastereoselective Claisen condensation, a Rh-catalyzed Reformatsky reaction, and an AZADO-catalyzed oxidative beta-lactonization reaction as the key reactions.

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