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Controlled stoichiometric synthesis of DNA-quantum dot conjugates using Ni-mediated coordination chemistry

  作者 KWON HAEJIN; HONG SUKMIN; KIM HEEYEON; CHOI YOUNGSEON; KIM JAESEUNG; SONG RITA  
  选自 期刊  Chemical Communications;  卷期  2010年46-47;  页码  8959-8961  
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[摘要]An oligonucleotide modified with Ni-nitrilotriacetate (NTA) was successfully synthesized and used for the stoichiometric functionalization of QDs. This synthetic approach allowed for the facile preparation of DNA-QD conjugates with a defined DNA/QD ratio using well-known Ni-histidine coordination chemistry. A FRET based DNA-QD nanoprobe was prepared using this method highlighting the great potential of this synthetic strategy.

 
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