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Cytotoxic Profile and Peculiar Reactivity with Biomolecules of a Novel "Rule-Breaker" Iodidoplatinum(II) Complex

  作者 MESSORI LUIGI; CASINI ANGELA; GABBIANI CHIARA; MICHELUCCI ELENA; CUBO LETICIA; RIOSLUCI CARLA; PADRON JOSE M; NAVARRORANNINGER CARMEN; QUIROGA ADORACION G  
  选自 期刊  ACS Medicinal Chemistry Letters;  卷期  2010年1-8;  页码  381-385  
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[摘要]Novel and surprising biological properties were disclosed for the platinum(II) complex cis-diiodidodiisopropylamineplatinum(II). Remarkably this new platinum(II) complex manifests pronounced antiproliferative properties in vitro, in some cases superior to those of cisplatin. A peculiar reactivity with the model protein cytochrome c was indeed highlighted based on the loss of amine ligands and retention of iodides.

 
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