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[摘要]：Amadacycline (PTK-0796) is an aminomethylcycline antibiotic with a broad spectrum of antibacterial activity The agent showed patent in vitro activity against multidrug-resistant and -susceptible Gram-positive e, Cram-negative, anaerobic and atypical bacteria, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium and penicillin-resistant Streptococcus pneumoniae Amadacycline demonstrated superior in vivo activity to other antibiotics, including vancomycin, linezolid and minocycline, against infections caused by various bacterial pathogens and its activity was not affected by the presence of other antibiotics In patients with complicated skin and skin structure infections, amadacycline and linezolid showed comparable safety and efficacy profiles No discontinuations due to adverse events and no serious drug-related adverse events were reported in the amadacycline group Clinical trials of both oral and intravenous formulations of amadacycline have been completed |
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