Synthesis and biological property of some novel 1,3,4-oxadiazoles

[摘要]：A series of biphenyl-1,3,4-oxadiazoles namely 5-[substituted-(1,1'-biphenyl)-3-yl]-1,3,4-oxadiazole-2 (3H)-thiones and its S-alkyl derivatives have been synthesized by multi step organic synthesis involving Suzuki-Miyaura coupling using palladium catalyst. The synthesized compounds were characterized by H-1 NMR, C-13 NMR, F-19 NMR, IR and LCMS spectroscopic properties. They were tested for their antimicrobial and analgesic activities. Some of them showed significant activity. (C) 2010 Elsevier Masson SAS. All rights reserved

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