[摘要]：Six transition metal compounds of Schiff base ligands were evaluated for the inhibitory activity on jack bean urease, of which compounds 2-6 were determined by single crystal X-ray analysis. It was found that copper(II) complexes 1 and 4 showed strong inhibitory activity against jack bean urease (IC50 = 0.52 and 0.46 mu M). compared with acetohydroxamic acid (IC50 = 42.12 mu M) as a positive reference Cobalt(II), nickel(II) and zinc(II) compounds also exhibited potent inhibitory activity (IC50 = 3.88-25.20 mu M). A docking analysis using the AUTODOCK 4.0 program could explain the inhibitory activities of 1 and 4 against urease. (C) 2010 Elsevier Masson SAS All rights reserved.
