Synthesis, characterization and cytotoxicity of mixed-ligand complexes of palladium(II) with aromatic diimine and 4-toluenesulfonyl-L-amino acid dianion

[摘要]：Eight new palladium(II) complexes (1a-2d) with 4-toluenesulfonyl-L-amino acid dianion and diimine (bipy and phen) have been synthesized and characterized by elemental analysis, IR, UV, H-1 NMR, C-13 NMR and mass spectra techniques. Crystal structure of the complex (2d) has been determined by X-ray diffraction analysis. The cytotoxicity was tested by MTT and SRB assays. The results indicate that the complexes (1a-2d) have selectivity against tested carcinoma cell lines. The complex (2c) has the best cytotoxicity among the eight complexes, moreover its cytotoxicity is better than that of cisplatin against BGC-823, Bel-7402 and KB cell lines. It suggests that both aromatic diimine and 4-toluenesulfonyl-L-amino acid have important effect on cytotoxicity. (C) 2010 Elsevier Masson SAS. All rights reserved.

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