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Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain

作者	Tyagarajan, S; Chakravarty, PK; Zhou, BS; Taylor, B; Eid, R; Fisher, MH; Parsons, WH; Wyvratt, MJ; Lyons, KA; Klatt, T; Li, XH; Kumar, S; Williams, B; Felix, J; Priest, BT; Brochu, RM; Warren, V; Smith, M; Garcia, M; Kaczorowski, GJ; Martin, WJ; Abbadie, C; McGowan, E; Jochnowitz, N; Weber, A; Duffy, JL

选自	期刊 Bioorganic & Medicinal Chemistry Letters; 卷期 2010年20-24; 页码 7479-7482

关联知识点

[摘要]：A series of novel biphenyl pyrazole dicarboxamides were identified as potential sodium channel blockers for treatment of neuropathic pain. Compound 20 had outstanding efficacy in the Chung rat spinal nerve ligation (SNL) model of neuropathic pain. (C) 2010 Elsevier Ltd. All rights reserved.
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