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[摘要]：Areas covered in this review: This review highlights the different strategies reported to inhibit NF-kappa B signaling in CLL cells. They include both I kappa B kinase inhibitors and several natural compounds that act at different steps of the pathway. What the reader will gain: Targeting NF-kappa B leads to apoptosis of CLL cells, corroborating the role of NF-kappa B in the survival and clonal expansion of these tumoral cells. Moreover, several studies confirmed a synergistic effect between NF-kappa B inhibitors and other antitumoral agents and that inhibition of NF-kappa B could overcome the microenvironmental protection of CLL cells. Take home message: NF-kappa B is a relevant target in CLL and inhibitors of this prosurvival pathway, alone or in combination, represent a novel therapeutic strategy for the treatment of CLL patients. |
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