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[摘要]：An antiplasmodial bioguided investigation of the EtOAc extract of the aerial parts of Teucrium ramosissimum led to isolation and identification of three sesquiterpenoids, teucmosin, 4 alpha-hydroxy-homalomenol C, 1 beta,4 beta,7 alpha-trihydroxy-8,9-eudesmene and two trinorsesquiterpenoids, 4 beta-hydroxy-11,12,13-trinor-5-eudesmen-1,7-dione and 1 beta,4 beta-dihydroxy-11,12,13-trinor-8,9-eudesmen-7-one together with five known sesquiterpenoids, oplopanone, homalomenol C, oxo-T-cadinol, 1 beta,4 beta,6 beta-trihydroxyeudesmane, 1 beta,4 beta,7 alpha-trihydroxyeudesmane and four flavonoids, 5-hydroxy-7,4'-dimethoxyflavone, salvigenin. genkwanin and cirsimaritin. The structures and the relative stereochemistry were elucidated by extensive spectroscopic studies including 1D and 2D NMR and mass spectrometry (MS). Homalomenol C, 4 beta-hydroxy-11,12,13-trinor-5-eudesmen-1,7-dione, oxo-T-cadinol and 1 beta,4 beta,6 beta-trihydroxyeudesmane displayed a significant in vitro antiplasmodial activity against Plasmodium falciparum with IC50 values ranging from 1.2 to 5.0 mu g/ml. Furthermore, no cytotoxicity was observed upon the human diploid lung cell line MRC-5 for these compounds. (C) 2009 Elsevier Ltd. All rights reserved. |
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