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[摘要]：Research into lipid peroxidation-induced protein modification has been ongoing for many years Recent studies on lipo-oxidation shows the occurrence of another type of protein modification, amide-type adduct formation by lipid hydroperoxide, as well as classical aldehyde-derived protein modifications The amide-type modifications can be either classified as alkylamide and carboxyalkylamide according to the formed structures As an alkylarmde-type adduct, N-epsilon(hexanoyl)lysine can be formed by the reaction of peroxidized n - 6 fatty acid with lysine N epsilon-(propanoyl)lysine is considered to be generated from oxidation of n - 3 fatty acid with lysine The generation pattern of both might be useful for classification of which fatty acids are more involved in oxidation in vivo Since the alkylamide type-adducts are relatively stable and detectable from biological specimens like urine, these adducts, especially N epsilon-(hexanoyl)lysine, are used as reliable markers for not only oxidative stress evaluation but also development of functional food (C) 2010 Elsevier Inc All rights reserved |
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