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Click-Engineered, Bioresponsive, Drug-Loaded PEG Spheres

  作者 Yap, HP; Johnston, APR; Such, GK; Yan, Y; Caruso, F  
  选自 期刊  ADVANCED MATERIALS;  卷期  2009年21-43;  页码  4348-4348  
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[摘要]A click-chemistry approach to synthesize bioresponsive poly(ethylene glycol acrylate) particles is described. The particles are loaded with a model anticancer drug (doxorubicin, DOX), and undergo simultaneous particle deconstruction and DOX release upon specific activation by the simulated environment of the cellular cytoplasm.

 
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