Ring-Closing of 1,7-and 1,8-Enynes of Propargylic O,O-Acetals by Ruthenium-Catalysed Intramolecular Metathesis

[摘要]：Acyclic 1,7- and 1,8-enynes with the alkyne moiety directly connected to the asymmetric carbon of an ethyl acetal have been obtained in two steps from the corresponding aldehydes. Ring-closing metathesis of these enynes delivered the corresponding six- and seven-membered cyclic 1,3-dienes in moderate-to-excellent yields. A competitive ethylene insertion into the alkyne moiety leading to trienes was observed for some substrates depending on their structure and relative configuration.

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