Catalytic Asymmetric Synthesis of Quaternary alpha-Hydroxy Trifluoromethyl Phosphonate via Chiral Aluminum(III) Catalyzed Hydrophosphonylation of Trifluoromethyl Ketones

[摘要]：The chiral hydrogenated tridentate Schiff base aluminum(III) complex has been first applied in the catalytic enantioselective hydrophosphonylation of trifluoromethyl ketones. The side reactions related to phospha-Brook rearrangement were completely avoided, and the corresponding quaternary a-hydroxy trifluoromethyl phosphonates have been first synthesized in good yields with high enantioselectivities (up to 90% ee).

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