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Chiral Phosphoric Acid-Catalyzed Enantioselective Transfer Hydrogenation of ortho-Hydroxyaryl Alkyl N-H Ketimines

  作者 NGUYEN THANH BINH; BOUSSEROUEL HADJIRA; WANG QIAN; GUERITTE FRANCOISE  
  选自 期刊  Organic Letters;  卷期  2010年12-20;  页码  4705-4707  
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[摘要]The first enantioselective chiral phosphoric acid-catalyzed transfer hydrogenation of unprotected ortho-hydroxyaryl alkyl N-H ketimines using Hantszch di-tert-butyl ester as a reductant is reported. A variety of ortho-hydroxybenzylamines were obtained in good to excellent yields and enantiomeric excesses

 
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