Verticilactam, a New Macrolactam Isolated from a Microbial Metabolite Fraction Library

[摘要]：Systematic isolation of microbial metabolites has been performed to construct microbial metabolite libraries or fraction libraries. A novel macrolactam, verticilactam (1), was isolated from a library of Streptomyces spiroverticillatus JC-8444 The structure was determined on the basis of NMR and mass spectrometric measurements. 1 had a unique 16-membered macrolactam skeleton including a beta-keto-amide moiety

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