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[摘要]:The synthesis and chemoselective study of a novel series N-methyl-2-methylthio-tetrahydropyrimidines and or N-methyl-2-methylthiodihydropyrimidines, from the cyclocondensation reaction of beta-alkoxyvinyl trihalomethyl ketones (enones) with 1,2-dimethylisothiourea sulfate is described. It was found that the chemoselectivity depends on both the reaction conditions and the steric and electronic effects of the substituents on the enones. |
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