Facile Synthesis of 2,4-Diamino-6-alkyl- or 6-Aryl-Pyrimidine Derivatives

[摘要]：Facile methods were developed to prepare a series of 6-phenyl and 6-alkyl-2,4-diaminopyrimidine derivatives. The pyrimidine ring of the final products was constructed by treatment of a 1,3-dicarbonyl derivative with an amidine or guanidine. The 6-phenyl-pyrimidine derivatives were also prepared by Suzuki coupling reaction, using 2-methylthio-4,6-dichloropyrimidine as the starting material.

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