MICROWAVE ASSISTED RAPID PREPARATION OF N-ALKYL-2-PYRIDONES UNDER NEUTRAL CONDITIONS BY HILBERT-JOHNSON REACTION

[摘要]：The reactions of 2-methoxypyridine with haloalkanes without solvent and catalyst under microwave irradiation (100-200 degrees C, 5 min) yielded the corresponding N-alkyl-2(1H)-pyridones in good to moderate yields. However, the reactions were sensitive to length of haloalkanes. In contrast, the reactions of 2-alkoxypyridines with corresponding iodoalkanes under microwave irradiation (150 degrees C) proceeded rapidly without catalyst and solvent, and were complete within 5 min to afford N-alkyl-2(1H)-pyridones in good to excellent yields.

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