10-23 DNAzyme modified with (2 ' R)- and (2 ' S)-2 '-deoxy-2 '-C-methyluridine in the catalytic core

[摘要]：The catalytic core of a 10-23 DNAzyme was modified using (2'R), (2'S)-2'-deoxy-2'-C-methyluridine and LNA-T. Catalytic activities under pseudo first order conditions were compared at different Mg2+ concentrations, indicating that certain 2'-C-methyl modified DNAzymes have significant activities. Resistance against MCF-7 cell lysate and endonuclease RQ1 was also measured, showing that the introduction of 2'-C-methyl-2'-deoxynucleosides increased the stability. (C) 2010 Elsevier Ltd. All rights reserved.

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