2 '-Fluorosugar analogues of the highly potent anti-varicella-zoster virus bicyclic nucleoside analogue (BCNA) Cf 1743

[摘要]：We report the preparation of 2 '-alpha-F, 2 '-beta-F and 2 ',2 '-difluoro analogues of the leading anti-varicella zoster virus (VZV) pentylphenyl BCNA Cf 1743. VZV thymidine kinase showed the highest phosphorylating capacity for the beta-fluoro derivative, that retained equal antiviral potency as the parent compound. In contrast, the alpha-fluoro- and 2 ',2 '-difluoro BCNA derivatives were markedly less (similar to 100-fold) antivirally active. (C) 2009 Elsevier Ltd. All rights reserved.

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