Bioorganic & Medicinal Chemistry Letters ——个性化文献订阅—

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Phenylaminopyrimidines as inhibitors of Janus kinases (JAKs)

作者	Burns, CJ; Bourke, DG; Andrau, L; Bu, XY; Charman, SA; Donohue, AC; Fantino, E; Farrugia, M; Feutrill, JT; Joffe, M; Kling, MR; Kurek, M; Nero, TL; Nguyen, T; Palmer, JT; Phillips, I; Shackleford, DM; Sikanyika, H; Styles, M; Su, S; Treutlein, H; Zeng, J; Wilks, AF

选自	期刊 Bioorganic & Medicinal Chemistry Letters; 卷期 2009年19-20; 页码 5887-5892

关联知识点

[摘要]：A series of phenylaminopyrimidines has been identified as inhibitors of Janus kinases (JAKs). Development of this initial series led to the potent JAK2/JAK1 inhibitor CYT387 (N-(cyanomethyl)-4-[2-[[4-(4-morpholinyl) phenyl]amino]-4-pyrimidinyl]-benzamide). Details of synthesis and SAR studies of these compounds are reported. (C) 2009 Elsevier Ltd. All rights reserved.
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