Small kinase assay panels can provide a measure of selectivity

[摘要]：In this Letter, a novel strategy for assessment of ligand promiscuity is described. By using a carefully selected small set of kinases together with multivariate statistical methods, a measure of selectivity can be estimated. This will facilitate an appropriate selection of compounds for further development in lead generation and optimization. (C) 2009 Elsevier Ltd. All rights reserved.

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