Synthetic substrate for application in both high and low throughput assays for botulinum neurotoxin B protease inhibitors

[摘要]：A FRET peptide substrate was synthesized and evaluated for enzymatic cleavage by the BoNT/B light chain protease. The FRET substrate was found to be useful in both a high throughput assay to uncover initial 'hits' and a low throughput HPLC assay to determine kinetic parameters and modes of inhibition. (C) 2009 Elsevier Ltd. All rights reserved.

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