[摘要]：The association between impairment in mitochondrial muscle fat oxidative capacity (OXFA) and occurrence of insulin resistance was examined in 14 healthy trained men (age, 24 +/- 4 yr) submitted to 4 weeks of training cessation. Training stop induced a significant decrease in mRNA levels of proteins involved in muscle fat metabolism, particularly PPAR alpha (-58%, P < 0.01) and PGC-1 alpha (-30%, P < 0.05), a 21% reduction in OXFA (P < 0.01), and reduced fat oxidation during moderately intense exercise (P < 0.05). In contrast, there was no significant alteration in insulin sensitivity. In conclusion, decline in OXFA is a rapid metabolic event following training cessation. It is involved in the regulation of whole body fat balance but not in the deterioration of insulin sensitivity. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
