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Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

作者	Lieberman-Aiden, E; van Berkum, NL; Williams, L; Imakaev, M; Ragoczy, T; Telling, A; Amit, I; Lajoie, BR; Sabo, PJ; Dorschner, MO; Sandstrom, R; Bernstein, B; Bender, MA; Groudine, M; Gnirke, A; Stamatoyannopoulos, J; Mirny, LA; Lander, ES; Dekker, J

选自	期刊 Science; 卷期 2009年326-5950; 页码 289-293

关联知识点

[摘要]：We describe Hi-C, a method that probes the three-dimensional architecture of whole genomes by coupling proximity-based ligation with massively parallel sequencing. We constructed spatial proximity maps of the human genome with Hi-C at a resolution of 1 me
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