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Synthesis and Biological Evaluation of Caffeic Acid 3,4-Dihydroxyphenethyl Ester

  作者 Zhang, ZZ; Xiao, BH; Chen, Q; Lian, XY  
  选自 期刊  Journal of natural products;  卷期  2010年73-2;  页码  252-254  
  关联知识点  
 

[摘要]A high-yield synthesis of caffeic acid 3,4-dihydroxyphenethyl ester (1) has been achieved through Knoevenagel condensation of 3,4-dihydroxybenzaldehyde and 3,4-dihydroxyphenethyl monomalonate as the key Step. Compound 1 was tested against a 56-cell-line cytotoxicity panel and for its free-radical-scavenging activity in the DPPH test.

 
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