Amphidinol 17 (AM 17; 1), 1 novel amphidinol, has been isolated from I Bahamas strain of Amphidinium carterae. This new congener contains the singature hairpin region and a Delta(6) polyene arm, whereas the polyol arm is distinct from those of other amphidinols. The pattern of acetate incorporation in 1 was directly determined by feeding it single labeled Substrate, [2-C-13]acetate. While the highly conserved regions within the amphidinol family of AM17 have exhibited identical occurrences of cleaved acetates to Other amphidinols for which the biosynthesis has been explored. the polyol arm for AM17 displays I higher degree of nascent chain processing that shows similarities to amphidinolide biosynthesis. AM17 exhibited in EC50 of 4.9 mu M it a hemolytic assay using human red blood cells but displayed no detectable antifungal activity.
