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[摘要]：In a survey of plants from Ecuador with antiprotozoal activity, Jacaranda glabra was found to show promising activity against the Plasmodium falciparum K1 strain. Subsequently, activity-guided isolation of the dichloromethane extract from the leaves of J. glabra afforded four new phenylethanoid glucosides containing jacaranone-type moieties (1-4), named jacaglabrosides A-D. Their chemical structures were identified using NMR spectroscopy and MS techniques. The compounds were found to be active in vitro against the P. falciparum K1 strain (IC50 1, 1.02; 2, 0.56; 3, 0.56; and 4, 0.55 mu g/mL) and generally possessed a low cytotoxicity toward L-6 cells, with the exception of compound 1 (IC50 1, 8.3; 2, >90; 3, 87; and 4, 85 mu g/mL). |
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