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Cytotoxic Acylphloroglucinol Derivatives from the Twigs of Garcinia cowa

  作者 Xu, G; Kan, WLT; Zhou, Y; Song, JZ; Han, QB; Qiao, CF; Cho, CH; Rudd, JA; Lin, G; Xu, HX  
  选自 期刊  Journal of natural products;  卷期  2010年73-2;  页码  104-108  
  关联知识点  
 

[摘要]An unusual polyprenylated acylphloroglucinol derivative unsubstituted at C-2 and C-6, garcicowin A (1), together with three other new (garcicowins B-D, 2-4) and nine known analogues, wits isolated and characterized front the twigs of Garcinia cowa. The structures of 1-4 were elucidated by interpretation of their spectroscopic data. The compounds isolated were evaluated for their cytotoxicity against two cancer cell lines (HT-29 and HCT116) and against normal colon cells (CCD-18Co), and the results demonstrated their selective toxicity toward the cancer cells.

 
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