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Biscarpamontamines A and B, an Aspidosperma-Iboga Bisindole Alkaloid and an Aspidosperma-Aspidosperma Bisindole Alkaloid, from Tabernaemontana sphaerocarpa

  作者 Zaima, K; Hirata, T; Hosoya, T; Hirasawa, Y; Koyama, K; Rahman, A; Kusumawati, I; Zaini, NC; Shiro, M; Morita, H  
  选自 期刊  Journal of natural products;  卷期  2009年72-9;  页码  1686-1690  
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[摘要]Two new bisindole alkaloids, biscarpamontamine A (1), possessing an aspidosperma-iboga-type skeleton, and biscarpamontamine B (2), having an aspidosperma-aspidosperma-type skeleton, were isolated from stems of Tabernaemontana sphaerocarpa, and their structures were elucidated on the basis of spectroscopic data analysis. The absolute configuration of biscarpamontamine B (2) was established by comparison of its CD spectrum and with that of vobtusine (3). Biscarpamontamine B (2) showed potent cytotoxicity against various human cancer cell lines.

 
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