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Bioactive Constituents of the Stem Bark of Mitrephora glabra

  作者 Li, C; Lee, D; Graf, TN; Phifer, SS; Nakanishi, Y; Riswan, S; Setyowati, FM; Saribi, AM; Soejarto, DD; Farnsworth, NR; Falkinham, JO; Kroll, DJ; Kinghorn, AD; Wani, MC; Oberlies, NH  
  选自 期刊  Journal of natural products;  卷期  2009年72-11;  页码  1949-1953  
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[摘要]Bioactivity-guided fractionation of the stem bark of Mitrephora glabra yielded nine compounds, comprising three entkaurenoids (1-3), five polyacetylenic acids/esters (4-8), and one aporphine alkaloid, liriodenine (9). The structures of the six new compounds (1-3, 5, 7, and 8) were determined by spectroscopic data interpretation. All compounds were evaluated for their inhibitory activities against a panel of cancer cell lines and a battery of microorganisms.

 
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