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Bioactive Bromophycolides R-U from the Fijian Red Alga Callophycus serratus

  作者 Lin, AS; Stout, EP; Prudhomme, J; Le Roch, K; Fairchild, CR; Franzblau, SG; Aalbersberg, W; Hay, ME; Kubanek, J  
  选自 期刊  Journal of natural products;  卷期  2010年73-2;  页码  275-278  
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[摘要]Four new bromophycolides, R-U (1-4), were isolated from the Fijian red alga Callophycus serratus and were identified by 1D and 2D NMR and mass spectroscopic analyses. These compounds expand the known structural variety of diterpene-benzoate macrolides and exhibited modest cytotoxicity toward selected human cancer cell lines. Bromophycolide S (2) also showed submicromolar activity against the human malaria Parasite Plasmodium falciparum.

 
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