[摘要]：A new 1-imidazoyl-3-carboxy-6-hydroxy-beta-carboline alkaloid. named hyrtiocarboline (1), was isolated from a Papua New Guinea marine sponge, Hyrtios reticulatus. The structure Was elucidated front spectroscopic data, including H-1-N-15 HMBC NMR experiments, Which provided complementary N-15 chemical shift information ill support of the structure. This compound showed selective antiproliferative activity against H522-T1 non-small cell lung, MDA-MB-435 melanoma, and U937 lymphoma cancer cell lines.
