[摘要]：GBS (Group B Streptococus) requires capsular Sia (sialic acid) for virulence and partially modifies this sugar by O-acetylation. In die present paper we describe serotype-specific patterns of GBS Sia O-acetylation that can be manipulated by genetic and biochemical means. In vitro and in vivo assays demonstrate that this subtle modification attenuates GBS Sia-mediated neutrophil suppression and animal virulence.
