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Practical Synthesis of 5-Substituted Tetrazoles under Microwave Irradiation

  作者 ROH JAROSLAV; ARTAMONOVA TATJANA V; VAVROVA KATERINA; KOLDOBSKII GRIGORII I; HRABALEK ALEXANDR  
  选自 期刊  Synthesis;  卷期  2009年-13;  页码  2175-2178  
  关联知识点  
 

[摘要]5-Substituted tetrazoles were prepared by treatment of nitriles with sodium azide and triethylammonium chloride in nitrobenzene in a microwave reactor. This practical method combines the advantages of previous procedures, including good-to-excel lent yields, short reaction times, and easy isolation of the product. Moreover, sterically hindered tetrazoles, as well as those deactivated by electron-donating groups, can be prepared.

 
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