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A Straightforward Synthesis of (S)-Anabasine via the Catalytic, Enantioselective Vinylogous Mukaiyama-Mannich Reaction

  作者 GIERA DAVID S; SICKERT MARCEL; SCHNEIDER CHRISTOPH  
  选自 期刊  Synthesis;  卷期  2009年-22;  页码  3797-3802  
  关联知识点  
 

[摘要]The tobacco alkaloid (S)-anabasine was synthesized by a straightforward 4-step sequence with the catalytic enantioselective vinylogous Mannich reaction as a key step. Only 3 mol% of a structurally optimized chiral BINOL-based phosphoric acid was employed to control the absolute configuration of the natural product.

 
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