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Organocatalytic Highly Enantioselective Mannich-Type Reactions of Fluoromalonate with N-Boc-Aldimines

  作者 LEE JU HEE; KIM DAE YOUNG  
  选自 期刊  Synthesis;  卷期  2010年-11;  页码  1860-1864  
  关联知识点  
 

[摘要]The catalytic enantioselective Mannich reaction promoted by chiral bifunctional organocatalysts is described. The treatment of diethyl fluoromalonate with N-Boc-aldimines under mild reaction conditions afforded the corresponding beta-amino-beta-fluoromalonates with excellent enantioselectivity (93-97% ee).

 
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